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e-Prescribing is the practice of writing prescriptions electronically through an EHR or similar type of software application. The e-Prescription can be electronically routed to the patient's pharmacy of choice via internal fax modem, email, or other electronic means.

e-Prescribing is considered superior to traditional paper prescriptions due to the legibility of the information. An added benefit of e-prescribing is the access to the latest drug interaction information (see DUR) as well as up-to-date payer formularies.